Methionine analogues as inhibitors of methionyl-tRNA synthetase

Authors
Lee, J Kang, MK Chun, MW Jo, YJ Kwak, JH Kim, S
Citation
J. Lee et al., Methionine analogues as inhibitors of methionyl-tRNA synthetase, BIOORG MED, 8(24), 1998, pp. 3511-3514
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3511 - 3514
Database
ISI
SICI code
0960-894X(199812)8:24<3511:MAAIOM>2.0.ZU;2-9
Abstract
A series of methionine analogues have been synthesized as inhibitors of met hionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methioni ne hydroxamate 20 has proved to be the best inhibitor of the enzyme with K- i = 19 mu M and showed a growth inhibition against E.coli JM 109, P. vulgan is 6059 and C. freundii 8090. (C) 1998 Elsevier Science Ltd. All rights res erved.