Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare

Authors
Banskota, AH Tezuka, Y Phung, LK Tran, KQ Saiki, I Miwa, Y Taga, T Kadota, S
Citation
Ah. Banskota et al., Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare, BIOORG MED, 8(24), 1998, pp. 3519-3524
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3519 - 3524
Database
ISI
SICI code
0960-894X(199812)8:24<3519:CCTFCQ>2.0.ZU;2-W
Abstract
Seven novel cycloartane-type triterpenes were isolated from Combretum quadr angulare, and their structures were elucidated on the basis of spectral ana lysis. All these compounds were tested for their cytotoxicity against murin e colon 26-L5 carcinoma cells. Methyl quadrangularate B (2) and methyl quad rangularate D (4) exhibited potent cytotoxicity having ED50 values 9.54 and 5.42 mu M, respectively. (C) 1998 Elsevier Science Ltd. All rights reserve d.