Phenylpiperazine derivatives with strong affinity for 5HT(1A), D-2A and D-3 receptors

Authors
Teran, C Santana, L Uriarte, E Fall, Y Unelius, L Tolf, BR
Citation
C. Teran et al., Phenylpiperazine derivatives with strong affinity for 5HT(1A), D-2A and D-3 receptors, BIOORG MED, 8(24), 1998, pp. 3567-3570
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3567 - 3570
Database
ISI
SICI code
0960-894X(199812)8:24<3567:PDWSAF>2.0.ZU;2-X
Abstract
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The a ffinities of these compounds for DA (D-2A, D-3) and 5HT(1A) receptors were evaluated for their ability to displace [H-3]-raclopride and [H-3]-8-OH-DPA T respectively from their specific binding sites. The affinities of the tar get compounds were all in the nanomolar range and followed the order 5-HT1A > D-2 > D-3 (C) 1998 Elsevier Science Ltd. All rights reserved.