Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists

Authors
Chambers, RJ Antognoli, GW Cheng, JB Kuperman, AV Liston, TC Marfat, A Owens, BS Pillar, JS Shirley, JT Watson, JW
Citation
Rj. Chambers et al., Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists, BIOORG MED, 8(24), 1998, pp. 3577-3582
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3577 - 3582
Database
ISI
SICI code
0960-894X(199812)8:24<3577:DO2CLR>2.0.ZU;2-3
Abstract
A new series of cysLT(1) receptor antagonists represented by CP-288,886 (7) and CP-265,298 (8) were developed which are equipotent to clinical cysLT(1 ) receptor antagonists Zafirlukast (1) and Pranlukast (2). (C) 1998 Elsevie r Science Ltd. All rights reserved.