The solid phase synthesis of a series of tri-substituted hydantoin ligandsfor the somatostatin SST5 receptor

Authors
Scicinski, JJ Barker, RD Murray, PJ Jarvie, EM
Citation
Jj. Scicinski et al., The solid phase synthesis of a series of tri-substituted hydantoin ligandsfor the somatostatin SST5 receptor, BIOORG MED, 8(24), 1998, pp. 3609-3614
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3609 - 3614
Database
ISI
SICI code
0960-894X(199812)8:24<3609:TSPSOA>2.0.ZU;2-7
Abstract
A series of trisubstituted hydantoins has been prepared by a versatile soli d phase route employing primary alcohols, amines and amino acids as the mon omeric building blocks. Several compounds showed submicromolar affinity in binding assays at recombinant human somatostatin receptors. (C) 1998 Elsevi er Science Ltd. All rights reserved.