Design and synthesis of novel conformationally restricted HIV protease inhibitors

Authors
Salituro, FG Baker, CT Court, JJ Deininger, DD Kim, EE Li, BQ Novak, FM Rao, BG Pazhanisamy, S Porter, MD Schairer, WC Tung, RD
Citation
Fg. Salituro et al., Design and synthesis of novel conformationally restricted HIV protease inhibitors, BIOORG MED, 8(24), 1998, pp. 3637-3642
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3637 - 3642
Database
ISI
SICI code
0960-894X(199812)8:24<3637:DASONC>2.0.ZU;2-0
Abstract
A set of HIV protease inhibitors represented by compound 2 has previously b een described. Structural and conformational analysis of this compound sugg ested that conformational restriction of the P-1/P-2 portion of the molecul e could lead to a novel set of potent protease inhibitors. Thus, probe comp ounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease. (C) 1998 Elsevier Science Ltd. All rights reserved.