N-6-(5,6-epoxynorbornyl)adenosine analogs as A(1) adenosine agonists

Authors
Wright, DMJ Baker, SP Stewart, SG Scammells, PJ
Citation
Dmj. Wright et al., N-6-(5,6-epoxynorbornyl)adenosine analogs as A(1) adenosine agonists, BIOORG MED, 8(24), 1998, pp. 3647-3648
Citations number
4
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
24
Year of publication
1998
Pages
3647 - 3648
Database
ISI
SICI code
0960-894X(199812)8:24<3647:NAAAAA>2.0.ZU;2-T
Abstract
A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing o xygenated substituents in the N-6 position have been synthesised and evalua ted as A(1)-adenosine receptor ligands. Compound 9 emerged with potent affi nity (EC50 = 1.1 nM). (C) 1998 Elsevier Science Ltd. All rights reserved.