Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa

Authors
Fevig, JM Cacciola, J Alexander, RS Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation
Jm. Fevig et al., Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa, BIOORG MED, 8(22), 1998, pp. 3143-3148
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3143 - 3148
Database
ISI
SICI code
0960-894X(19981117)8:22<3143:POMAAP>2.0.ZU;2-8
Abstract
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an a ttractive strategy for the discovery of novel antithrombotic agents. Here w e describe a series of meta-amidino-N,N-disubstituted anilines as structura lly simple and very potent inhibitors of factor Xa. (C) 1998 The DuPont Pha rmaceuticals Company. Published by Elsevier Science Ltd. All rights reserve d.