Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D

Authors
Carroll, CD Johnson, TO Tao, S Lauri, G Orlowski, M Gluzman, IY Goldberg, DE Dolle, RE
Citation
Cd. Carroll et al., Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D, BIOORG MED, 8(22), 1998, pp. 3203-3206
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3203 - 3206
Database
ISI
SICI code
0960-894X(19981117)8:22<3203:EOASSC>2.0.ZU;2-9
Abstract
A structure-based 18,900-member combinatorial library was synthesized conta ining a statine template and three cyclic diamino acids as potential P-1', P-2-P-4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of sel ective inhibitors for each enzyme. (C) 1998 Elsevier Science Ltd. All right s reserved.