10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties

Authors
Muller, K Breu, K
Citation
K. Muller et K. Breu, 10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties, BIOORG MED, 8(22), 1998, pp. 3211-3216
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3211 - 3216
Database
ISI
SICI code
0960-894X(19981117)8:22<3211:1AIOKG>2.0.ZU;2-Q
Abstract
Work aimed at further improving the benefit to risk ratio of the antipsoria tic agent anthralin has led to 10-omega-phenylalkyl-9(10H)-anthracenones, m embers of which are equally potent as inhibitors of the growth of HaCaT ker atinocytes. In contrast to anthralin, induction of membrane injury is stron gly reduced as documented by the release of LDH activity from cytoplasm of keratinocytes. (C) 1998 Elsevier Science Ltd. All rights reserved.