Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd(4)C and beta-D-Fd(4)C

Authors
Chen, SH Lin, S King, I Spinka, T Dutschman, GE Gullen, EA Cheng, YC Doyle, TW
Citation
Sh. Chen et al., Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd(4)C and beta-D-Fd(4)C, BIOORG MED, 8(22), 1998, pp. 3245-3250
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3245 - 3250
Database
ISI
SICI code
0960-894X(19981117)8:22<3245:SACEOT>2.0.ZU;2-G
Abstract
The synthesis of beta-D-Fd(4)C was achieved in a stereoselective fashion fi om D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd(4)C was compared with that of beta-L-Fd(4)C and 3TC (Lamivudine). Of the three agen ts compared, beta-L-Fd(4)C was found to be the most potent antiviral agent. (C) 1998 Elsevier Science Ltd. All rights reserved.