Growth inhibitory effect of juvenile hormone analogues on epimastigotes ofTrypanosoma cruzi

Authors
Rodriguez, JB Zhong, L Docampo, R Wimmer, Z Gros, EG
Citation
Jb. Rodriguez et al., Growth inhibitory effect of juvenile hormone analogues on epimastigotes ofTrypanosoma cruzi, BIOORG MED, 8(22), 1998, pp. 3257-3260
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3257 - 3260
Database
ISI
SICI code
0960-894X(19981117)8:22<3257:GIEOJH>2.0.ZU;2-8
Abstract
Several compounds, structurally related to the insect growth regulator Feno xycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease. Some of t hese drugs were shown to be potent growth inhibitors of this parasite. All of these drugs had previously presented juvenoid activity on several non-re lated bug species such as Tenebrio molitor, Galleria mellonella, Dysdercus cingulatos, and Pyrrhocoris apterus. (C) 1998 Elsevier Science Ltd. All rig hts reserved.