Mixed-backbone oligonucleotides as second-generation antisense agents withreduced phosphorothioate-related side effects

Authors
Zhou, WQ Agrawal, S
Citation
Wq. Zhou et S. Agrawal, Mixed-backbone oligonucleotides as second-generation antisense agents withreduced phosphorothioate-related side effects, BIOORG MED, 8(22), 1998, pp. 3269-3274
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
8
Issue
22
Year of publication
1998
Pages
3269 - 3274
Database
ISI
SICI code
0960-894X(19981117)8:22<3269:MOASAA>2.0.ZU;2-1
Abstract
Mixed-backbone oligonucleotides containing alternative phosphorothioate and phosphodiester linkages in the 2'-O-methylribonucleosides segment show inc reased affinity with complementary targets, increased stability towards nuc leases in vitro and in vivo, and reduced phosphorothioate-related prolongat ion of partial thromboplastin time compared to phosphorothioate oligodeoxyn ucleotides, thereby providing antisense agents with reduced side effects. ( C) 1998 Elsevier Science Ltd. All rights reserved.