Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex

Authors
Chen, JC Li, JY Liang, KW Huang, YK
Citation
Jc. Chen et al., Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex, BRAIN RES, 816(1), 1999, pp. 220-224
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
816
Issue
1
Year of publication
1999
Pages
220 - 224
Database
ISI
SICI code
0006-8993(19990116)816:1<220:NFPTBS>2.0.ZU;2-J
Abstract
We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amph etamine. Further, the treatment with NPFF decreased the levels of serotonin , and increased the glutamate and GABA content in the medial prefrontal cor tex of amphetamine-sensitized rats. The results suggest that NPFF may modul ate the neuronal process of amphetamine addiction. (C) 1999 Elsevier Scienc e B.V. All rights reserved.