Hydroxylamine blocks adenosine A(1) receptor-mediated inhibition of synaptic transmission in rat hippocampus

Authors
Fowler, JC Partridge, LD Gervitz, L
Citation
Jc. Fowler et al., Hydroxylamine blocks adenosine A(1) receptor-mediated inhibition of synaptic transmission in rat hippocampus, BRAIN RES, 815(2), 1999, pp. 414-418
Citations number
21
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
815
Issue
2
Year of publication
1999
Pages
414 - 418
Database
ISI
SICI code
0006-8993(19990109)815:2<414:HBAARI>2.0.ZU;2-9
Abstract
The nitric oxide donor hydroxylamine (NH2OH) induced a transient depression of the evoked synaptic potential recorded in the rat hippocampal CA1 regio n. This depression was abolished with an adenosine A(1) antagonist, 8-cyclo pentyltheophylline. In addition, hydroxylamine reversed adenosine A(1) rece ptor-mediated inhibition of the evoked population spike, the fEPSP and the intracellularly recorded EPSP. The inhibitory modulation of adenosine A(1) receptor activation by hydroxylamine suggests the presence of a potent endo genous regulatory site. (C) 1999 Elsevier Science B.V. All rights reserved.