The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases

Although it is well established that immune mechanisms contribute to the pa thogenesis of chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis, the actual events that trigger the immunological pathwa ys resulting in these skin diseases are not well understood. Colonization a nd infection with Staphylococcus aureus and streptococci has been reported to exacerbate AD and psoriasis, Recent studies demonstrating that bacterial toxins can act as superantigens provide mechanism(s) by which S. aureus an d streptococci could mediate an inflammatory skin lesion that consists pred ominantly of activated T-cells and monocytes, This review will explore the diverse mechanisms by which bacterial superantigens can induce skin inflamm ation following systemic or local infection. These observations provide a n ew direction for the development of novel approaches for the treatment of s kin inflammation.