H. Kienapfel et al., RECOMBINANT AND NONRECOMBINANT FACTOR-XIII AND ITS EFFECT ON BONE INGROWTH AND STRENGTH OF FIXATION, Archives of orthopaedic and trauma surgery, 116(4), 1997, pp. 239-243
Thirty cylindrical, commercially pure, titanium fiber, porous-coated T
i6Al4V implants were inserted press-fit into the proximal humeral port
ion of 30 sheep humeri to determine the systemic effect of recombinant
factor XIII and placenta-derived factor XIII concentrate on bone ingr
owth and strength of fixation. For both the recombinant factor XIII an
d the factor XIII concentrate group, the volume of bone ingrowth and t
he strength of fixation were higher than for the control specimens. Ho
wever, the difference was only significant for the factor XIII concent
rate group.