Vl. Kumar et al., Comparative analysis of epidermal growth factor receptor mRNA levels in normal, benign hyperplastic and carcinomatous prostate, CANCER LETT, 134(2), 1998, pp. 177-180
Epidermal growth factor receptor (EGFR), a mediator of mitogenic activity o
f epidermal growth factor and transforming growth factor-alpha, has been sh
own to be associated with tumour progression. We have detected a level of E
GFR transcript in normal, hyperplastic (BPH) and carcinomatous (CaP) prosta
te tissues by cytoplasmic dot hybridization. Our results show that the majo
rity of CaP cases (62% of untreated cases and 71% of treated cases) were po
sitive for EGFR mRNA while about 50% of normal and BPH cases were positive
for EGFR mRNA, The level of EGFR transcript was significantly higher in the
untreated CaP group as compared to the normal group (P < 0.05), while the
difference in the normal and BPH groups was not statistically significant.
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