Growth hormone-releasing peptide (GHRP)

Growth hormone-releasing peptides and non-peptides (GHRPs, GHRP-GHS) are a new chemical class of GH secretagogues with a chemistry that ranges from sm all synthetic peptides to peptidomimetics. They release GPI in animals and humans by a unique dual and complementary action on the hypothalamus and pi tuitary. Although the present GHRPs are of unnatural origin, evidence by a number of investigators is gradually accumulating to support that GHRP refl ects the GH-releasing action of a new natural hypothalamic hormone yet to b e isolated and identified. Despite the de novo origin of GHRP, a major reas on for the persistent investigation is because of the possible practical di agnostic and therapeutic value in humans as well as the potential theoretic al value of new insight into the physiological regulation of GI-I secretion .