Synthesis of acyclic nucleotide analogues derived from 6-(sec- or tert-alkyl)purines via coupling of 6-chloropurine derivatives with organocuprates

Authors
Dvorakova, H Dvorak, D Holy, A
Citation
H. Dvorakova et al., Synthesis of acyclic nucleotide analogues derived from 6-(sec- or tert-alkyl)purines via coupling of 6-chloropurine derivatives with organocuprates, COLL CZECH, 63(12), 1998, pp. 2065-2074
Citations number
19
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
63
Issue
12
Year of publication
1998
Pages
2065 - 2074
Database
ISI
SICI code
0010-0765(199812)63:12<2065:SOANAD>2.0.ZU;2-C
Abstract
Coupling of 9-[2-(diisopropyloxyphosphonylmethoxy)ethyl]-6-chloropurine (23 ) (and (R)-9-[2-(diisopropyloxyphosphonylmethoxy)propyl]-6-chloropurine (24 ), respectively) with organocuprates derived from Grignard reagents afforde d after deprotection 6-(sec- or tert-alkyl) substituted phosphonates 31-36. As a model a series of 6-(sec- or tert-alkyl)purines 2-12 was also prepare d.