Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

Authors
Furukawa, T Yatsuoka, T Youssef, EM Abe, T Yokoyama, T Fukushige, S Soeda, E Hoshi, M Hayashi, Y Sunamura, M Kobari, M Horii, A
Citation
T. Furukawa et al., Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer, CYTOG C GEN, 82(3-4), 1998, pp. 156-159
Citations number
14
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
82
Issue
3-4
Year of publication
1998
Pages
156 - 159
Database
ISI
SICI code
0301-0171(1998)82:3-4<156:GAODAD>2.0.ZU;2-I
Abstract
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreat ic cancer. This gene is composed of three exons, and two forms of alternati vely spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of th e full-length transcripts were observed in some cell lines, which may sugge st some role for DUSP6 in pancreatic carcinogenesis.