Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2 beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F

Authors
van den Maagdenberg, AMJM Schepens, JTG Schepens, MTM Pepers, B Wieringa, B van Kessel, AG Hendriks, WJAJ
Citation
Amjm. Van Den Maagdenberg et al., Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2 beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F, CYTOG C GEN, 82(3-4), 1998, pp. 153-155
Citations number
17
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
82
Issue
3-4
Year of publication
1998
Pages
153 - 155
Database
ISI
SICI code
0301-0171(1998)82:3-4<153:AOPTGE>2.0.ZU;2-1
Abstract
The receptor-type protein tyrosine phosphatase IA-2 beta gene (mouse gene s ymbol Ptprn2) encodes a major autoantigen in insulin-dependent diabetes mel litus. We physically mapped Ptprn2 by fluorescence in situ hybridization to band F of mouse chromosome 12, a region that lacks diabetes susceptibility loci. The mapping confirms the proposed synteny of mouse 12F with band q36 of human chromosome 7.