Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

Authors
Izquierdo, MA Scheffer, GL Schroeijers, AB de Jong, MC Scheper, RJ
Citation
Ma. Izquierdo et al., Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP, CYTOTECHNOL, 27(1-3), 1998, pp. 137-148
Citations number
59
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
CYTOTECHNOLOGY
ISSN journal
09209069 → ACNP
Volume
27
Issue
1-3
Year of publication
1998
Pages
137 - 148
Database
ISI
SICI code
0920-9069(1998)27:1-3<137:VRTADD>2.0.ZU;2-0
Abstract
In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug r esistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.