Cirrhosis occurs in 20-50% of patients with hepatitis C and is thought to b
e irreversible. We describe two patients with cirrhosis secondary to hepati
tis C in whom the extensive fibrosis and cirrhosis appeared to regress in r
esponse to treatment with interferon-alpha (IFN-alpha). Both patients were
in the early stages of cirrhosis, class A in the Child-Pugh classification,
total score 5 for each patient. Both responded fully to IFN-alpha and had
normalization of all liver function tests and disappearance of hepatitis C
viral RNA. Liver biopsies, performed before and after treatment, were coded
unpaired by patient, combined with 21 liver biopsies from eight other pati
ents with chronic hepatitis, and read independently by two pathologists usi
ng the Knodell scoring system. Knodell scores decreased from 14 to 3.5 and
from 13.5 to 4 in these two patients. Cirrhosis and extensive fibrosis, pre
sent at baseline, were not present on follow-up liver biopsies, which were
of sufficient size to reduce the likelihood of sampling error. We conclude
that hepatic fibrosis and clinically early cirrhosis may be reversible in s
ome patients with hepatitis C who respond to treatment with IFN-alpha.