Cadmium-induced time-dependent oxidative stress in liver of mice: a correlation with kidney

In the present investigation a time-responsive oxidative stress, both in li ver and kidney were carried out following cadmium (Cd) exposure. Cadmium wa s administered subcutaneously on each other day in normal saline solution. Mice were sacrificed on the 15th, 30th and 45th days post-exposure. For oxi dative stress study different biochemical markers, e.g. lipid peroxidation (LPO), reduced glutathione (GSH) and glutathione S-transferase (GST) activi ty were considered. Time-responsive exponential increase in the lipid perox idation and decrease in glutathione level and glutathione S-transferase act ivity occurred both in hepatic and renal tissues following cadmium treatmen t. Though both the organs responded in a similar fashion, their magnitude o f response was found to be different. Body weight did not differ but relati ve liver and kidney weight were found to be significantly increased at diff erent time points. The possible mechanism of time-dependent cadmium-induced toxic effects and relation between hepatic and renal biochemical response have been discussed. (C) 1998 Elsevier Science B.V. All rights reserved.