INVOLVEMENT OF THE PRESYNAPTIC DOPAMINERG IC RECEPTORS IN THE MECHANISM OF REACTIVATING EFFECTS OF THE GABA-BENZODIAZEPINE-IONOPHORE COMPLEX BLOCKADE

The changes in reactivating efficiency of the GABA-benzodiazepine-iono phore complex blockade were examined in mice after preliminary activat ion or inhibition of dopamine autoreceptors by (+)3PPP (2 mg/kg) and h aloperidol (0,01 mg/kg), The passive avoidance learning task and amnes ia produced by detention of a mouse in the dangerous compartment were used. The pretest injections of bicuculline (1 mg/kg), picrotoxin (1 m g/kg), and flumazenil (10 mg/kg) recovered the passive avoidance respo nse in mice injected with saline before training. Pretreatment with th e dopamine autoreceptor agonist and antagonist prevented from the reco very of amnestic memory trace induced by blockade of GABA-benzodiazepi ne-ionophore complex components. The results imply the involvement of dopamine/GABA-dependent mechanism in the modulation of memory trace re trieval.