Synthesis of 4-silyl-substituted methyl nicotinates via silylcupration of N-acylpyridinium salts

Authors
Hosl, CE Wanner, KT
Citation
Ce. Hosl et Kt. Wanner, Synthesis of 4-silyl-substituted methyl nicotinates via silylcupration of N-acylpyridinium salts, HETEROCYCLE, 48(12), 1998, pp. 2653-2659
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
48
Issue
12
Year of publication
1998
Pages
2653 - 2659
Database
ISI
SICI code
0385-5414(199812)48:12<2653:SO4MNV>2.0.ZU;2-1
Abstract
A general synthetic method for the preparation of 4-silyl-substituted methy l nicotinates (5) is described. The reaction sequence includes a silylcupra tion of the N-acylated 3-methoxypyridinium salts (2) followed by oxidation of the resulting dihydropyridines (3) to give 5.