Increasing attention is being paid to the role of nutrition in cancer. Diet
ary measures, such as decreased consumption of calories, fat, alcohol and s
moked or pickled foods have been shown to reduce the incidence of specific
"adult" cancers, while increased dietary fiber appears to have a protective
role. However, no clear scientific evidence exists that dietary manipulati
on is a successful primary therapy for established cancer. A significant pe
rcentage of adult and child cancer patients take unproven therapies during
their illness. Alternative nutritional therapies, of which there is a wide
variety, are the commonest of these reflecting current public interest in "
natural" remedies. The efficacy and potential toxicity of commonly utilized
dietary therapies are here reviewed, in particular the macrobiotic philoso
phy, the Gerson diet, the Livingstone diet, and the use of vitamin and mine
ral therapy. While details may differ, most alternative approaches involve
fresh whole foods, with strong emphasis on low-fat vegetarian diet. Most ar
e nutritionally adequate, at least for adults. No anti-cancer diet has been
shown to cure established cancers, even those whose incidence is decreased
by dietary changes. Careful dietary manipulation may at least improve qual
ity of life for adult cancer patients, and, together with conventional ther
apy, may prolong survival in selected cancer patients. Assessment by carefu
lly controlled prospective clinical trials is essential; those in pediatric
patients must be controlled very strictly, since tumors in children have n
ot been shown to be influenced by diet, and the diets described may be inad
equate for children with malignant disease. (C) 1998 Wiley-Liss, Inc.