Increased QT dispersion in the absence of QT prolongation in patients withBehcet's disease and ventricular arrhythmias

In Behcet's disease, prominent clinical manifestations include involvement of mucocutaneous, ocular, gastrointestinal, respiratory, neurologic, urogen ital, articular and cardiovascular systems. Patients with Behcet's disease have higher incidence of ventricular arrhythmia than healthy subjects. Howe ver there is a little information about the mechanism of ventricular arrhyt hmias in Behcet's disease. The aim of the study was to investigate whether dispersion of ventricular repolarisation was an arrhythmogenic mechanism. Q T dispersion parameters were measured in 73 Behcet patients and QT dispersi on was defined as the difference between the maximum and minimum QT interva l in any of the 12 leads of surface electrocardiogram. Corrected QT dispers ion for heart rate was calculated by Bazett's formula. The results were com pared with the data from 51 matched controls without a history of cardiac d isease. We found QT dispersion was greater in Behcet patients (58+/-12 vs. 37+/-8 ms, P=0.001) as was corrected QT dispersion (81+/-14 vs. 52+/-11 ms, P=0.001). There was no significant difference in minimum or maximum QT int ervals between Behcet patients and controls (P>0.05). We found a correlatio n between QT dispersion and grade of premature ventricular complexes (r=0.7 , P=0.002). Our findings suggest that increased dispersion of repolarisatio n may account for the development of ventricular arrhythmias in Behcet's di sease. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.