The S phase: Beginning, middle, and end: A perspective

Events in the S phase of the cell cycle have been investigated to a relativ ely limited extent in comparison with those in G1 and M phases. Four aspect s of S are briefly discussed in this report: (1) the final biochemical step permitting initiation of DNA synthesis, (2) determination of replication t iming of individual genes and its mechanism, (3) S phase processes that lea d to the onset of M phase, and (4) resetting the S-phase machinery. J. Cell . Biochem. Suppls. 30/31 :1-7, 1998. (C) 1998 Wiley-Liss, Inc.