Initiation of DNA replication in eukaryotic chromosomes

Authors
Citation
Ml. Depamphilis, Initiation of DNA replication in eukaryotic chromosomes, J CELL BIOC, 1998, pp. 8
Citations number
37
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN journal
07302312 → ACNP
Year of publication
1998
Supplement
30-31
Database
ISI
SICI code
0730-2312(1998):<8:IODRIE>2.0.ZU;2-S
Abstract
Our understanding of the process by which eukaryotes regulate initiation of DNA replication has made remarkable advances in the past few years, thanks in large part to the explosion of genetic and biochemical information on t he budding yeast, Saccharomyces cerevisiae. At least three major concepts h ave emerged: 1) The sequence of molecular events that determines when repli cation begins and how frequently each replication site is used are conserve d among most, if not all, eukaryotes; 2) specific replication origins are u sed in most, if not all, eukaryotes that consist of a flexible modular anat omy; and 3) epigenetic factors such as chromatin structure and nuclear orga nization determine which of many potential replication origins are used at different stages in animal development. Thus, the current state of our know ledge suggests a simple unifying concept-all eukaryotes utilize the same ba sic proteins and DNA sequences to initiate replication, but the metazoa can change both the number and locations of replication origins In response to the demands of animal development. J. Cell. Biochem. Suppls. 30/31:8-17, 1 998. Published 1998 Wiley-Liss, Inc.dagger.