Control of bone formation and resorption: Biological and clinical perspective

Bone is subject to continuous breakdown (resorption) by osteoclasts and reb uilding (formation) by osteoblasts in order to fulfill its functions. Most bone diseases including osteoporosis are due to excessive bone resorption r elative to formation. Recent research has generated new insights into the r egulation of osteoclast and osteoblast differentiation and function and the interaction between the two cell types. There is increased awareness of th e role of mechanical stimuli in bone homeostasis and by inference the funct ion of bone cells. This information can lead to new therapeutic modalities for maintaining a healthy skeleton into old age. J. Cell. Biochem. Suppls. 30/31 :55-61, 1998. (C) 1998 Wiley-Liss, Inc.