We present the most extensive neuropsychological and language assessment ye
t reported of patients diagnosed with Floating-Harbor Syndrome (FHS), a rar
e genetic condition characterized by dysmorphid figures, short stature, and
speech-onset delay. This is also the second reported occurrence of both a
mother and daughter with FHS. Whereas the child demonstrated gross deficits
in verbal expression, speech and language problems were largely ameliorate
d in the mother. Neuropsychological assessment also revealed a strikingly s
imilar pattern of cognitive problems additional to language dysfunction, in
cluding difficulties with attention, mathematical, and visuospatial abiliti
es. A mood disorder continued to be quite disabling for the mother.