Influence of obesity and body fat distribution on postprandial lipemia andtriglyceride-rich lipoproteins in adult women

We know that upper body obesity is associated with metabolic complications, but we don't know how regional body fat distribution influences postprandi al lipemia in obese adults. Thus, this study explored the respective effect s of android or gynoid types of obesity and fasting triglyceridemia on post prandial Lipid metabolism and especially triglyceride-rich lipoproteins. Tw enty-four obese and 6 lean normotriglyceridemic women (control), age 24-57 yr, were enrolled. Among obese women with an android phenotype, 9 exhibited normal plasma triglyceride levels (mean: 1.38 mmol/L) (NTAO), and 7 displa yed a frank hypertriglyceridemia (mean: 2.40 mmol/L) (HTAO). The 8 patients with a gynoid phenotype had normal triglyceride levels (mean: 1.00 mmol/L) (GO). All were given a mixed test meal providing 40 g triglycerides. Serum and incremental chylomicron triglycerides 0-7 h areas under the curve (AUC s) as well as triglyceride levels in apoB-48-containing triglyceride-rich l ipoprotein (TRLs) or chylomicrons were significantly higher in HTAOs and NT AOs than in GOs and controls postprandially. The size of chylomicron partic les was bigger in controls and GOs than in HTAOs and NTAOs postprandially. Android obese subjects showed abnormally elevated fasting apoB-48 and apoB- 100 triglyceride-rich lipoprotein (TRL) levels. Most abnormalities that wer e found correlated to plasma levels of insulin and apoC-III. In conclusion, an abnormal postprandial lipid pattern is a trait of abdominal obesity eve n without fasting hypertriglyceridemia.