Wg. Mccluggage et al., Small intestinal ulceration secondary to carcinoid tumour arising in a Meckel's diverticulum, J CLIN PATH, 52(1), 1999, pp. 72-74
Citations number
13
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
A solitary small intestinal ulcer associated with a carcinoid tumour in a n
earby Meckel's diverticulum was found in a 77 year old man presenting with
massive rectal bleeding. Angiography and a radioisotope study localised the
bleeding to the ileum. At operation, the Meckel's diverticulum was identif
ied, with bleeding from an ulcer just distal to it. Pathological examinatio
n revealed a small carcinoid tumour confined to the Meckel's diverticulum.
Close to the opening of the diverticulum, within the ileum, a well demarcat
ed ulcer was present. Histology showed a non-specific ulcer which eroded a
large blood vessel. This is the first documented occurrence of solitary sma
ll intestinal ulceration in association with a carcinoid tumour. Carcinoid
tumour should be added to the list of possible causes of small intestinal u
lceration. The ulceration may be secondary to release of cytokines by the t
umour.