Molecular moment similarity between clozapine and substituted [(4-phenylpiperazinyl)-methyl] benzamides: Selective dopamine D4 agonists

Moment descriptors of the molecular charge and mass distributions are inves tigated within the context of molecular similarity. Euclidean distances in the moment descriptor space are shown to yield molecular proximities in acc ord with chemical intuition for a substituted [(4-phenylpiperazinyl)-methyl ] benzamide series of dopamine D4 agonists. The proximity of the dopamine D 4 antagonist clozapine to the molecules of this series is also examined in the moment space.