In this paper, the problem of sequencing mixed-model assembly lines in case
of fixed rate launching and closed stations is considered. The problem con
sists of finding an intermixed sequence of different models of a basic prod
uct, which are jointly produced on an assembly line, such that customer dem
ands are fulfilled and total work overload is minimized. For solving this p
roblem an informed tabu search procedure with a pattern based vocabulary bu
ilding strategy is developed. Computational tests demonstrate that consider
able improvements are obtained by comparison to methods which do not incorp
orate such an approach.