Junctional tachycardias comprise several arrhythmia types with differing me
chanisms, principally involving the region of the atrioventricular (A-V) ju
nction. Neonatal radiofrequency catheter ablation has typically been reserv
ed for life-threatening, drug-refractory cases due to the unique concerns r
egarding patient size and development. We performed radiofrequency catheter
ablation on two neonates with incessant, rapid junctional tachycardias and
hemodynamic compromise after failing conventional medical therapy. This re
port describes 2 neonates who underwent emergent radiofrequency catheter ab
lation, and compares these two patients to a larger pediatric catheter abla
tion patient cohort. Both neonates had an acutely successful outcome and we
re able to be discharged within a week of the ablation procedure, Fluorosco
py time and total procedure time were shorter in these two patients than in
the course of the average pediatric catheter ablation, Though long-term de
velopmental consequences of neonatal catheter ablation are yet unknown, in
unique extreme situations, radiofrequency catheter ablation can be performe
d in neonates, as in older children and adults, without excessive acute mor
bidity.