A new prenylated flavonol, sophoflavescenol (1), together with five known f
lavonoids, kurarinol, kushenol K, kushenol H, trifolirhizin, and kuraidin,
were isolated from the roots of Sophora flavescens. The structure of 1 was
determined by spectroscopic analysis. Among the five known flavonoids, kura
rinol, kushenol K, and kushenol H showed weak antiviral activity against He
rpes simplex virus types I and II.