A new indole derivative from the red alga Chondria atropurpurea. Isolation, structure determination, and anthelmintic activity

Authors
Davyt, D Entz, W Fernandez, R Mariezcurrena, R Mombru, AW Saldana, J Dominguez, L Coll, J Manta, E
Citation
D. Davyt et al., A new indole derivative from the red alga Chondria atropurpurea. Isolation, structure determination, and anthelmintic activity, J NAT PROD, 61(12), 1998, pp. 1560-1563
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
61
Issue
12
Year of publication
1998
Pages
1560 - 1563
Database
ISI
SICI code
0163-3864(199812)61:12<1560:ANIDFT>2.0.ZU;2-I
Abstract
Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopi c data and chemical transformations. A new natural product, S-indoleacrylam ide (4), and the previously described chondriamides A and B (1, 2) and 3-in doleacrylic acid (5) were also isolated. The anthelmintic activities of com pounds 1, 3, 4, and 6 (the O,N-1,N-1-trimethyl derivative of compound 2) ag ainst Nippostrongylus brasiliensis in vitro were evaluated.