Calix[4]arene-based receptors with hydrogen-bonding groups immersed into alarge cavity

A one-pot procedure, which combines the Ritter and Friedel-Crafts reactions , produced the first members of a new type of calix[4]arene-based receptors . The cavity in these receptors is formed by a calix[4]arene framework fixe d in the cone conformation and bulky adamantyl or (and) phenylacetylene moi eties. Amido and amino groups were used as potential hygrogen bond donors. Preliminary studies revealed interesting complexation properties, in partic ular, the tetrahedral recognition of water molecules performed by one of th e receptors.