Analytical techniques used to study the degradation of proteins and peptides: physical instability

Citation
Jle. Reubsaet et al., Analytical techniques used to study the degradation of proteins and peptides: physical instability, J PHARM B, 17(6-7), 1998, pp. 979-984
Citations number
44
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
17
Issue
6-7
Year of publication
1998
Pages
979 - 984
Database
ISI
SICI code
0731-7085(199809)17:6-7<979:ATUTST>2.0.ZU;2-U
Abstract
The physical instability of proteins and peptides as well as the various an alytical techniques used to study the various aspects of physical instabili ty have been reviewed. Physical instability of proteins and peptides involv e changes in secondary, tertiary and quaternary structures of these compoun ds. After a general introduction of the subject the literature data of thes e changes and their analytical aspects have been summarized in a Table. (C) 1998 Published by Elsevier Science B.V. All rights reserved.