Estimation of aqueous solubility for some guanine derivatives using partition coefficient and melting temperature

Authors
Kristl, A
Citation
A. Kristl, Estimation of aqueous solubility for some guanine derivatives using partition coefficient and melting temperature, J PHARM SCI, 88(1), 1999, pp. 109-110
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN journal
00223549 → ACNP
Volume
88
Issue
1
Year of publication
1999
Pages
109 - 110
Database
ISI
SICI code
0022-3549(199901)88:1<109:EOASFS>2.0.ZU;2-3
Abstract
Aqueous solubilities for some guanine derivatives were estimated by semiemp irical equations developed by Yalkowsky and Valvani(1) using the data for p artition coefficient and melting temperature. It was shown that in the case of guanine derivatives examined in this study, the solubility values could not be estimated adequately by these equations.