Objective: To review the empirical, methodological, and conceptual limitati
ons of psychotherapy and pharmacotherapy for childhood and adolescent depre
ssion and to present descriptive data on key characteristics of a depressed
sample to illustrate gaps in treatment. Method: Interview-based assessment
of psychiatric features and psychosocial functioning, family psychopatholo
gy and marital adjustment, and child and parent stressful life events was p
erformed in a sample of 43 depressed youngsters seeking outpatient treatmen
t. Results: The empirical and conceptual review indicated that treatments b
ased on downward extensions of adult procedures are limited in number and s
uccess. Also, the treatments generally neglect the following characteristic
s revealed in the descriptive data: depressed youngsters have high rates of
recurrent depression and comorbid conditions, impaired academic and social
functioning, exposure to high rates of parental psychopathology, parental
assortative mating, severe marital dysfunction, and high rates of severe st
ressors. Conclusions: Treatments need to be informed by and address the act
ual characteristics of depressed youngsters and their environments, which a
re highly dysfunctional.