Iatrogenic Cushing's syndrome and steroid hepatopathy in a cat

The distinguishing clinical features of Gushing's syndrome in the cat inclu de very friable skin, a high incidence of diabetes mellitus, and the genera l absence of steroid hepatopathy, This case report describes a nine-year-ol d, spayed female domestic shorthair with triamcinolone-induced Gushing's sy ndrome. Unique to this cat were markedly elevated liver enzymes which promp ted an expanded clinical evaluation, An ultrasonographic-guided liver biops y demonstrated diffuse hepatocellular vacuolation that stained periodic aci d-Schiff (PAS) positive and was removed subsequently with diastase applicat ion, indicating glycogen accumulation. These findings are compatible with t he rarely seen syndrome of steroid hepatopathy in the cat.