Duodenal perforation in a cat following the administration of nonsteroidalanti-inflammatory medication

A one-year-old, female domestic shorthair was presented for septic peritoni tis 10 days following a routine ovariohysterectomy and subsequent oral admi nistration of carprofen. Exploratory laparotomy revealed a perforated duode num which was treated with a gastroduodenostomy (Billroth I) and open abdom en management. Etiology of the duodenal perforation was most likely due to the administration of carprofen, a nonsteroidal anti-inflammatory drug appr oved for Oral use in dogs only.