Effects of candesartan and PD123319 on responses to angiotensin II in the anesthetized mouse

The effects of candesartan (30 mu g/kg iv) and PD123319 (10 mg/kg iv) on ch anges in systemic arterial pressure in response to angiotensin II (AngII) w ere investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor respo nses to AngII were attenuated by candesartan but were not altered by PD1233 19. Neither candesartan nor PD123319 had a significant effect on baseline s ystemic arterial pressure or on the increase in arterial pressure in respon se to nonpinephrine, The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are media ted by AT(1) receptors and that AT(2) receptors do not modulate the presser response to AngII.