Melting curves of terfenadine crystallized from different solvents

Authors
Canotilho, J Costa, FS Sousa, AT Redinha, JS Leitao, MLP
Citation
J. Canotilho et al., Melting curves of terfenadine crystallized from different solvents, J THERM ANA, 54(1), 1998, pp. 139-149
Citations number
14
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
ISSN journal
13886150 → ACNP
Volume
54
Issue
1
Year of publication
1998
Pages
139 - 149
Database
ISI
SICI code
1388-6150(1998)54:1<139:MCOTCF>2.0.ZU;2-U
Abstract
Several samples of terfenadine prepared by crystallization from different s olvents under different experimental conditions were studied. The DSC curve s obtained at a heating rate of 1 degrees C min(-1) afforded the temperatur e of melting and the mole fractions of the components of each sample. Certa in of the samples were composed of two solid phases mixed in molar ratios v arying between nearly one and a single structural form. Three polymorphic f orms were identified.