Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers

Authors
Szpirer, C Tissir, F Riviere, M Van Vooren, P Kela, J Lallemand, F Gabant, P Hoebee, B Klinga-Levan, K Levan, G Szpirer, J
Citation
C. Szpirer et al., Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers, MAMM GENOME, 10(1), 1999, pp. 30-34
Citations number
35
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MAMMALIAN GENOME
ISSN journal
09388990 → ACNP
Volume
10
Issue
1
Year of publication
1999
Pages
30 - 34
Database
ISI
SICI code
0938-8990(199901)10:1<30:RC2AOT>2.0.ZU;2-L
Abstract
The rat Chromosome (Chr) 2 harbors several genes controlling tumor growth o r development, blood pressure, and non-insulin-dependent diabetes mellitus. We report that the region (2q1) containing the mammary susceptibility canc er gene Mcs1 also harbors the genes encoding cyclin B1, interleukin 6 signa l transducer (gp130), and proprotein convertase 1. We also generated 13 new anonymous microsatellite markers from Chr 2-sorted DNA. These markers, as well as a microsatellite marker in the cyclin B1 gene, were genetically map ped in combination with known markers. A cyclin B1-related gene was also cy togenetically assigned to rat Chr 11q22-q23.