Jl. Peirce et al., A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice, MAMM GENOME, 9(12), 1998, pp. 942-948
C57B1/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle
choice paradigm than do DBA/2J mice. In this paper we report the identific
ation of two new sex-specific alcohol preference (Alcp) loci. Melo and asso
ciates (1996) identified two loci: Alcp1, a male-specific locus on Chromoso
me (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr ll. We hav
e additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4
a female-specific locus on Chr I. We have also performed a statistical anal
ysis to exclude the possibility of undiscovered major alcohol preference lo
ci that are not sex-specific in our backcross paradigm. Our results indicat
e that alcohol preference in C57BL/6 mice, as measured in our backcross, is
largely controlled in a sex-specific manner.